【公開日：2024.07.25】【最終更新日：2024.06.20】

課題データ / Project Data

課題番号 / Project Issue Number

23NU0417

利用課題名 / Title

Physicochemical analysis of plasma irradiated liquids for cancer treatment

利用した実施機関 / Support Institute

名古屋大学 / Nagoya Univ.

機関外・機関内の利用 / External or Internal Use

内部利用（ARIM事業参画者以外）/Internal Use (by non ARIM members)

技術領域 / Technology Area

【横断技術領域 / Cross-Technology Area】（主 / Main）物質・材料合成プロセス/Molecule & Material Synthesis（副 / Sub）-

【重要技術領域 / Important Technology Area】（主 / Main）次世代バイオマテリアル/Next-generation biomaterials（副 / Sub）-

キーワード / Keywords

Zeta-potential, plasma treatment,生分解性材料/ Biodegradable material

利用者と利用形態 / User and Support Type

利用者名（課題申請者）/ User Name (Project Applicant)

Camelia Miron

所属名 / Affiliation

Center for Low-temperature Plasma Sciences, Nagoya University

共同利用者氏名 / Names of Collaborators in Other Institutes Than Hub and Spoke Institutes

ARIM実施機関支援担当者 / Names of Collaborators in The Hub and Spoke Institutes

Mayumi Nishimura

利用形態 / Support Type

（主 / Main）機器利用/Equipment Utilization（副 / Sub）-

利用した主な設備 / Equipment Used in This Project

NU-020：粒径測定装置 ゼータ電位・粒径測定システム(ゼータ電位、粒径・粒度分布）

報告書データ / Report

概要（目的・用途・実施内容）/ Abstract (Aim, Use Applications and Contents)

Plasma irradiated chitosan samples showed a selective cytotoxic effect on cancer cells. Particles of different size were formed during the plasma treatment, confirmed by AFM and XRD measurements. Zeta-potential and size measurements of the plasma irradiated samples are necessary for further applications in the medical field, such as liposomes. These structure are designed to include the palsma irradiated chitosan, therefore a thourough understanding of compounds and charging is necessary for the production of liposomes. 

実験 / Experimental

Zeta-potential was performed on Ar, Ar/N_2, Ar/N₂/O₂, and Ar/O₂ plasma-treated chitosan 0.5% samples by pulse electrical discharges for 5 minutes. No sample dilution or filtering was required.

結果と考察 / Results and Discussion

Zeta-potential showed positive values, slightly increased for the plasma-treated samples. The measurements of the particles size required a different holder and software program, and the results are not accurate for values higher than 1 μm. Therefore, these results for the particle size may not be considered correct using this device. The experiments may be repeated using sample filtering (0.45 μm, 0.2 μm filters). 

図・表・数式 / Figures, Tables and Equations

Table 1

その他・特記事項（参考文献・謝辞等） / Remarks(References and Acknowledgements)

成果発表・成果利用 / Publication and Patents

論文・プロシーディング（DOIのあるもの） / DOI (Publication and Proceedings)

口頭発表、ポスター発表および、その他の論文 / Oral Presentations etc.

特許 / Patents

特許出願件数 / Number of Patent Applications：1件
特許登録件数 / Number of Registered Patents：1件