【公開日：2023.07.31】【最終更新日：2023.05.30】
課題データ / Project Data
課題番号 / Project Issue Number
22UT0193
利用課題名 / Title
分子鋳型高分子を用いたタンパク質の電気化学計測
利用した実施機関 / Support Institute
東京大学
機関外・機関内の利用 / External or Internal Use
内部利用（ARIM事業参画者以外）/Internal Use (by non ARIM members)
技術領域 / Technology Area
【横断技術領域 / Cross-Technology Area】（主 / Main）計測・分析/Advanced Characterization（副 / Sub）-
【重要技術領域 / Important Technology Area】（主 / Main）次世代バイオマテリアル/Next-generation biomaterials（副 / Sub）その他/Others
キーワード / Keywords
ポリマー,電子顕微鏡/Electron microscopy,バイオセンサ/ Biosensor
利用者と利用形態 / User and Support Type
利用者名（課題申請者）/ User Name (Project Applicant)
MAN Youyuan
所属名 / Affiliation
東京大学
共同利用者氏名 / Names of Collaborators in Other Institutes Than Hub and Spoke Institutes
ARIM実施機関支援担当者 / Names of Collaborators in The Hub and Spoke Institutes
利用形態 / Support Type
（主 / Main）技術補助/Technical Assistance（副 / Sub）-
利用した主な設備 / Equipment Used in This Project
報告書データ / Report
概要（目的・用途・実施内容）/ Abstract (Aim, Use Applications and Contents)
MIP particles with a size of 70 nm were measured using Transmission Electron Microscopy (TEM).
実験 / Experimental
MIP particles were prepared using standard techniques and then deposited onto a carbon-coated copper grid. The grid was then placed in a TEM instrument and imaged under high vacuum conditions.
結果と考察 / Results and Discussion
Transmission Electron Microscopy (TEM) was used to analyze Molecularly Imprinted Polymer (MIP) particles with a size of 70 nm. The TEM images revealed that the MIP particles were well-defined, monodisperse, and had a spherical shape. The average particle size was found to be 70 nm, which was consistent with the size range reported in the literature for MIP nanoparticles.The size and shape of nanoparticles are important factors that influence their properties and behavior. The small size of the MIP particles makes them attractive for various applications, such as drug delivery and environmental sensing. The spherical shape of the MIP particles also enhances their stability and dispersibility in different solvents and media.The images also revealed that the MIP particles were well-dispersed and had no evidence of aggregation. This is a crucial factor for their potential applications, as aggregation can reduce the efficacy and stability of the nanoparticles. The good dispersibility of MIP particles suggests that they can be easily incorporated into various matrices or substrates to enhance their properties.In addition to the size and shape, the crystal structure of nanoparticles is also critical for their performance. The crystal structure of the MIP particles was investigated using selected area electron diffraction (SAED). The SAED pattern showed sharp and bright diffraction spots, which indicates that the MIP particles have a well-ordered crystal structure. The diffraction pattern was consistent with the crystal structure of the MIP monomers used to prepare the nanoparticles, confirming that the molecularly imprinted sites were maintained in the final product. In conclusion, the TEM analysis of MIP particles with a size of 70 nm showed that they had a well-defined size, shape, and crystal structure, making them a promising candidate for various applications, such as drug delivery, environmental monitoring, and chemical sensing. Further studies are needed to explore their potential in different fields and to optimize their properties for specific applications.
図・表・数式 / Figures, Tables and Equations
その他・特記事項（参考文献・謝辞等） / Remarks(References and Acknowledgements)
成果発表・成果利用 / Publication and Patents
論文・プロシーディング（DOIのあるもの） / DOI (Publication and Proceedings)
口頭発表、ポスター発表および、その他の論文 / Oral Presentations etc.
特許 / Patents
特許出願件数 / Number of Patent Applications：0件
特許登録件数 / Number of Registered Patents：0件