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New Platform for Culturing Stem Cells---Powerful new tool combines micro and nanotechnologies for culturing environment---

  On March 17, 2017, Kyoto University announced that a research group from Institute for Integrated Cell-Material Sciences (iCeMS) of the university has developed a new platform for culturing human pluripotent stem cells that provides far more improved control of culture conditions by using micro and nanotechnologies.  Details were published in Small with Associate Professor Ken-ichiro Kamei as lead author *.

Human pluripotent stems cells (hPSCs) hold great promise for tissue engineering, regenerative medicine and cell-based therapies. Since the environment around cells determines properties of tissues made from them, precise control of culturing environment for stem cell is highly requested.

  The research team has developed a hybrid array of integrated microfluidic channels and nanofibers, which can control soluble cell factors and extracellular matrix.  The array device has 48 micro chambers for cell cultivation with different environments.  This combinatorial approach provides effective tools to screen cellular microenvironments, and thus helps accelerate clinical applications of regenerative medicine using hPSCs.

* Ken-ichiro Kamei, Yasumasa Mashimo, Momoko Yoshioka, Yumie Tokunaga, Christopher Fockenberg, Shiho Terada, Yoshie Koyama, Minako Nakajima, Teiko Shibata-Seki, Li Liu, Toshihiro Akaike, Eiry Kobatake, Siew-Eng How, Motonari Uesugi and Yong Chen, "Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments", Small, First published: 8 March 2017, DOI: 10.1002/smll.201603104